ENAMEL MATRIX DERIVATIVE

• Contain amelogenin protein (found in enamel matrix)
• Can be used to reconstruct cementum,periodontal ligaments and alveolar bone during reconstructive surgeries.
• EMDOGAIN-commercial material available in market contain amelogenin protein.obtaine from dental follicles of piglet
• It is hypothesized that the application of these proteins onto root surfaces results in adsorption onto the root surface, and the promotion of cementoblast differentiation, cementum formation, and periodontal ligament and alveolar bone formation for true periodontal regeneration. 
• Till date technology hasn't been able to regenerate enamel.We have been able to get enamel matrix by using amelogenin protein but the basic problem encountered is that we are not able to control the mineralization  of this matrix.Research is going on.
• Nanospheres are the lastest advancement in dentistry.The assembly of amelogenin protein into nanospheres is postulated to be a key factor in the stability of enamel extracellular matrix framework, which provides the scaffolding for the initial enamel apatite crystals to nucleate and grow.